Welcome and Thanks for Visiting the Keats Lab Website
This site was developed with the goal of providing the international community a portal into the results of many of the projects ongoing in the lab. We plan to share many of our protocols, resources, and knowledge about the biology of multiple myeloma, the genetics of multiple myeloma, and the available model systems.
The Keats Lab is part of the Integrated Cancer Genomics Division at the Translational Genomics Research Institute (TGen) in Phoenix, Arizona. Our primary research interest is a blood cancer called multiple myeloma. This cancer is a relatively rare cancer diagnosed in approximately 20,000 people each year in the United States, which translates into an incidence of around 5.7/100,000 individuals. Unfortunately, this cancer is quite aggressive resulting in 3.6/100,000 deaths each year. Our primary focus is to understand the genetics underlying this cancer and what genetic events occur between diagnosis and the development of a tumor, which is refractory to therapy. The lab also has secondary interests in other blood cancers and immunodeficiency syndromes.
December 10, 2017 - ASH 2017 Oral Presentation
December 10, 2017 - ASH 2017 Poster Presentation
December 9, 2017 - ASH 2017 Oral Presentation
December 9, 2017 - ASH 2017 Poster Presentation
December 4, 2016 - ASH 2016 Poster Presentation
December 4, 2016 - ASH 2016 Oral Presentation
December 3, 2016 - ASH 2016 Oral Presentation
Dec 7, 2014
Ash Poster can be downloaded from this link. (ASH2014_Clonal_Modeling)
April 11, 2014 - SEARCHABLE DATABASE RELEASED
We have created a searchable website for the cell line characterization dataset. You can query by gene or by cell line to see which assumed somatic events have been detected. (https://myelomagenomics.tgen.org/)
December 12, 2013
Our poster presented at ASH is now available for download.
Nov 14, 2013 - DATA RELEASE UPDATE
Updated copy number tables are now available for the entire cell line series. This includes a raw data matrix and segmentation files.
April 17, 2013 - DATA RELEASE
Today we released the first preliminary full dataset of the cell line characterization project. You can access the preliminary mutation calls from the exome sequencing, and expression estimates from the mRNA sequencing on the Data Repository Page
April 10, 2013
Our poster on the genomic characterization of an isogenic UTX model system at AACR is available for download.
April 8, 2013
Check out the ecancer.tv interview of Dr. Keats after his presentation at the International Myeloma Workshop in Kyoto Japan.
April 4, 2013
The slides from the presentation Dr. Keats gave at the 14th International Myeloma Workshop are now available for download.
December 9, 2012
Our posters being presented at ASH are now available for download.
August 10, 2012
Today was the last official day for David who oversaw most of the cell line characterization project. In recognition of his hard work we are releasing the first segmentation file representing the CGH findings from the 33 cell lines completed to date. This file is design for the IGV browser available from the Broad Institute. Along with David's departure for graduate school we also had to say a very sad good-bye to Kim last week when she left for graduate school and sadly Amy will also be returning to school next week. Best of luck with your studies we will miss having all three of you around.