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WORK IN PROGRESS TO UPDATE THE WEBSITE, BETTER FUNCTIONS COMING SOON!!

Welcome and Thanks for Visiting the Keats Lab Website

This site was developed with the goal of providing the international community a portal into the results of many of the projects ongoing in the lab. We plan to share many of our protocols, resources, and knowledge about the biology of multiple myeloma, the genetics of multiple myeloma, and the available model systems.

The Keats Lab is part of the Integrated Cancer Genomics Division at the Translational Genomics Research Institute (TGen) in Phoenix, Arizona. Our primary research interest is a blood cancer called multiple myeloma. This cancer is a relatively rare cancer diagnosed in approximately 20,000 people each year in the United States, which translates into an incidence of around 5.7/100,000 individuals. Unfortunately, this cancer is quite aggressive resulting in 3.6/100,000 deaths each year. Our primary focus is to understand the genetics underlying this cancer and what genetic events occur between diagnosis and the development of a tumor, which is refractory to therapy. The lab also has secondary interests in other blood cancers and immunodeficiency syndromes.

News Updates:

December 10, 2017 - ASH 2017 Oral Presentation

Christofferson et al. Integrative analysis of the genomic landscape underlying multiple myeloma at diagnosis: An MMRF CoMMpass analysis (Click to Download PPTX or PDF)

December 10, 2017 - ASH 2017 Poster Presentation

Benard et al. FGFR3 mutations are an adverse prognostic factor in patients with t(4;14)(p16;q32) multiple myeloma. (Click to Download PDF)

December 9, 2017 - ASH 2017 Oral Presentation

Nasser et al. Comprehensive Identification of Fusion Transcripts in Multiple Myeloma: An MMRF CoMMpass Analysis . (Click to Download PPTX or PDF)

December 9, 2017 - ASH 2017 Poster Presentation

Skerget et al. A molecular analysis of cereblon-related immunomodulatory drug resistance in CoMMpass Multiple Myeloma Patient. (Click to Download PDF)

December 4, 2016 - ASH 2016 Poster Presentation

Benard et al. Reliability of Myeloma Model Systems: KP-6 is a Novel Hyperdiploid Cell Line. (Click to Download Poster)

December 4, 2016 - ASH 2016 Oral Presentation

Miller et al. A Comparison of Clinical FISH and Sequencing Based FISH Estimates in Multiple Myeloma: An MMRF CoMMpass Analysis. (Click to Download PPTX or PDF)

December 3, 2016 - ASH 2016 Oral Presentation

Keats et al. Molecular Predictors of Outcome and Drug Response in Multiple Myeloma: An Interim Analysis of the MMRF CoMMpass Study. (Click to Download PPTX or PDF)

Dec 7, 2014

Ash Poster can be downloaded from this link. (ASH2014_Clonal_Modeling)

April 11, 2014 - SEARCHABLE DATABASE RELEASED

We have created a searchable website for the cell line characterization dataset. You can query by gene or by cell line to see which assumed somatic events have been detected. (https://myelomagenomics.tgen.org/)

December 12, 2013

Our poster presented at ASH is now available for download.

Comprehensive Genomic Characterization of All Commercially and Non-Commercially Available Multiple Myeloma Cell Lines

Nov 14, 2013 - DATA RELEASE UPDATE

Updated copy number tables are now available for the entire cell line series. This includes a raw data matrix and segmentation files.

April 17, 2013 - DATA RELEASE

Today we released the first preliminary full dataset of the cell line characterization project. You can access the preliminary mutation calls from the exome sequencing, and expression estimates from the mRNA sequencing on the Data Repository Page

April 10, 2013

Our poster on the genomic characterization of an isogenic UTX model system at AACR is available for download.

Characterization of an Isogenic UTX model system in multiple myeloma

April 8, 2013

Check out the ecancer.tv interview of Dr. Keats after his presentation at the International Myeloma Workshop in Kyoto Japan.

April 4, 2013

The slides from the presentation Dr. Keats gave at the 14th International Myeloma Workshop are now available for download.

December 9, 2012

Our posters being presented at ASH are now available for download.

1) Comprehensive Characterization of Commercial Myeloma Cell lines

2) Genomic Analysis of the MM.1S and MM.1R Model System

August 10, 2012

Today was the last official day for David who oversaw most of the cell line characterization project. In recognition of his hard work we are releasing the first segmentation file representing the CGH findings from the 33 cell lines completed to date. This file is design for the IGV browser available from the Broad Institute. Along with David's departure for graduate school we also had to say a very sad good-bye to Kim last week when she left for graduate school and sadly Amy will also be returning to school next week. Best of luck with your studies we will miss having all three of you around.